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Loss and revival of androgen receptor signaling in advanced prostate cancer

Formaggio, Nicolò ; Rubin, Mark A. ; Theurillat, Jean-Philippe

In: Oncogene, 2021, vol. 40, no. 7, p. 1205–1216

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully i mplemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate...

NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy

Theurillat, Jean-Philippe ; Zürrer-Härdi, Ursina ; Varga, Zsuzsanna ; Storz, Martina ; Probst-Hensch, Nicole ; Seifert, Burkhardt ; Fehr, Mathias ; Fink, Daniel ; Ferrone, Soldano ; Pestalozzi, Bernhard ; Jungbluth, Achim ; Chen, Yao-Tseng ; Jäger, Dirk ; Knuth, Alexander ; Moch, Holger

In: Cancer Immunology, Immunotherapy, 2007, vol. 56, no. 11, p. 1723-1731