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Université de Fribourg

The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation

Vaux, Véronique De ; Pfefferli, Catherine ; Passannante, Myriam ; Belhaj, Khaoula ; Essen, Alina von ; Sprecher, Simon G. ; Müller, Fritz ; Wicky, Chantal

In: Aging Cell, 2013, p. –

The evolutionarily conserved nucleosome-remodeling protein Mi2 is involved in transcriptional repression during development in various model systems, plays a role in embryonic patterning and germ line development, and participates in DNA repair and cell cycle progression. It is the catalytic subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex, a key determinant of...