Université de Neuchâtel

Variability and Action Mechanism of a Family of Anticomplement Proteins in Ixodes ricinus

Couvreur, Bernard ; Beaufays, Jérôme ; Charon, Cédric ; Lahaye, Kathia ; Gensale, François ; Denis, Valérie ; Charloteaux, Benoît ; Decrem, Yves ; Prévôt, Pierre-Paul ; Brossard, Michel ; Vanhamme, Luc ; Godfroid, Edmond

In: PLoS One, 2008, vol. 3, no. 1, p. e1400 1-24

Background : Ticks are blood feeding arachnids that characteristically take a long blood meal. They must therefore counteract host defence mechanisms such as hemostasis, inflammation and the immune response. This is achieved by expressing batteries of salivary proteins coded by multigene families. Methodology/Principal Findings : We report the in-depth analysis of...

Université de Neuchâtel

Ixodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization

Beaufays, Jérôme ; Adam, Benoît ; Decrem, Yves ; Prévôt, Pierre-Paul ; Santini, Sébastien ; Brasseur, Robert ; Brossard, Michel ; Lins, Laurence ; Vanhamme, Luc ; Godfroid, Edmond

In: PLoS One, 2008, vol. 3, no. 12, p. e3941 1-11

Background : During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of the inflammatory response. Methodology/Principal Findings : Screening a cDNA library in association with RT-PCR and RACE methodologies allowed us to identify 14...

Université de Neuchâtel

Ir-LBP, an Ixodes ricinus Tick Salivary LTB4-Binding Lipocalin, Interferes with Host Neutrophil Function

Beaufays, Jérôme ; Adam, Benoît ; Menten-Dedoyart, Catherine ; Fievez, Laurence ; Grosjean, Amélie ; Decrem, Yves ; Prévôt, Pierre-Paul ; Santini, Sébastien ; Brasseur, Robert ; Brossard, Michel ; Vanhaeverbeek, Michel ; Bureau, Fabrice ; Heinen, Ernst ; Lins, Laurence ; Vanhamme, Luc ; Godfroid, Edmond

In: PLoS One, 2008, vol. 3, no. 12, p. e3987 1-13

Background : During their blood meal, ticks secrete a wide variety of proteins that can interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of the inflammatory response. Methodology/Principal Findings : We previously identified 14 new lipocalin genes in the tick Ixodes ricinus. One of them...