Université de Fribourg

Effects of the circadian rhythm gene period 1 (Per1) on psychosocial stress-Induced alcohol drinking

Dong, Li ; Bilbao, Ainhoa ; Laucht, Manfred ; Henriksson, Richard ; Yakovleva, Tatjana ; Ridinger, Monika ; Desrivieres, Sylvane ; Clarke, Toni-Kim ; Lourdusamy, Anbarasu ; Smolka, Michael N. ; Cichon, Sven ; Blomeyer, Dorothea ; Treutlein, Jens ; Perreau-Lenz, Stephanie ; Witt, Stephanie ; Leonardi-Essmann, Fernando ; Wodarz, Norbert ; Zill, Peter ; Soyka, Michael ; Albrecht, Urs ; Rietschel, Marcella ; Lathrop, Mark ; Bakalkin, Georgy ; Spanagel, Rainer ; Schumann, Gunter

In: American Journal of Psychiatry, 2011, vol. 168, no. 10, p. 1090-1098

Objective: Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1 (Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in ...