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Université de Fribourg

Laser speckle analysis synchronised with cardiac cycle

Zakharov, Pavel ; Scheffold, Frank ; Weber, Bruno

In: Proceedings SPIE, 2015, vol. 9540, p. 954008–954008–9

We present an improved Laser speckle imaging approach to investigate the cerebral blood flow response following function stimulation of a single vibrissa. By synchronising speckle analysis with the cardiac cycle we are able to obtain robust averaging of the correlation signals while at the same time removing the contributions due to the pulsation of blood flow and associated tissue adaptation....

Université de Fribourg

Laser Speckle Imaging of Cerebral Blood Flow

Zakharov, Pavel ; Scheffold, Frank ; Weber, Bruno

In: Optical Imaging of Neocortical Dynamics, 2014, vol. 85, p. 255–271

Optical imaging of cerebral hemodynamics has been used extensively to investigate the complex interplay between neurons and the blood-borne supply of oxygen and energy substrates. Among several techniques, the so-called laser speckle imaging (LSI) has found widespread applications for studying (patho-)physiological aspects of neurovascular coupling. LSI is a rather simple and cost-effective...

Université de Fribourg

Noise in laser speckle correlation and imaging techniques

Skipetrov, S. E. ; Peuser, Joern ; Cerbino, Roberto ; Zakharov, Pavel ; Weber, Bruno ; Scheffold, Frank

In: Optics Express, 2010, vol. 18, no. 14, p. 14519-14534

We study the noise of the intensity variance and of the intensity correlation and structure functions measured in light scattering from a random medium in the case when these quantities are obtained by averaging over a finite number N of pixels of a digital camera. We show that the noise scales as 1/N in all cases and that it is sensitive to correlations of signals corresponding to adjacent...