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Université de Fribourg

Dynamic laser speckle imaging of cerebral blood flow

Zakharov, Pavel ; Völker, A. C. ; Wyss, M. T. ; Haiss, F. ; Calcinaghi, N. ; Zunzunegui, C. ; Buck, Alfred ; Scheffold, Frank ; Weber, Bruno

In: Optics Express, 2009, vol. 17, no. 16, p. 13904-13917

Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed...

Université de Fribourg

Quantitative modeling of laser speckle imaging

Zakharov, Pavel ; Völker, Andreas ; Buck, Alfred ; Weber, Bruno ; Scheffold, Frank

In: Optics Letters, 2006, vol. 31, no. 23, p. 3465-3467

We have analyzed the image formation and dynamic properties in laser speckle imaging (LSI) both experimentally and with Monte Carlo simulation. We show for the case of a liquid inclusion that the spatial resolution and the signal itself are both significantly affected by scattering from the turbid environment. Multiple scattering leads to blurring of the dynamic inhomogeneity as detected by LSI....

Université de Fribourg

Optical imaging of the spatiotemporal dynamics of cerebral blood flow and oxidative metabolism in the rat barrel cortex

Weber, B. ; Burger, C. ; Wyss, M. T. ; Schulthess, G. K. von ; Scheffold, Frank ; Buck, Alfred

In: European Journal of Neuroscience, 2004, vol. 20, p. 2664-2670

Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa...