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Stochastic Models and Numerical Algorithms for a Class ofRegulatory Gene Networks

Fournier, Thomas ; Gabriel, Jean-Pierre ; Mazza, Christian ; Pasquier, Jerôme ; Galbete, José ; Mermod, Nicolas

In: Bulletin of Mathematical Biology, 2009, vol. 71, no. 6, p. 1394-1431

Stochastic Models and Numerical Algorithms for a Class of Regulatory Gene Networks

Fournier, Thomas ; Gabriel, Jean-Pierre ; Mazza, Christian ; Pasquier, Jérôme ; Galbete, José ; Mermod, Nicolas

In: Bulletin of Mathematical Biology, 2009, vol. 71, no. 6, p. 1394-1431

Regulatory gene networks contain generic modules, like those involving feedback loops, which are essential for the regulation of many biological functions (Guido et al. in Nature 439:856–860, 2006). We consider a class of self-regulated genes which are the building blocks of many regulatory gene networks, and study the steady-state distribution of the associated Gillespie algorithm by...

Stochastic models of a self regulated gene network

Fournier, Thomas ; Mazza, Christian (Dir.) ; Morgenthaler, Stephan (Codir.)

Thèse de doctorat : Université de Fribourg, 2008 ; no. 1620.

Steady-state expression of self-regulated genes

Fournier, Thomas ; Gabriel, Jean-Pierre ; Mazza, Christian ; Pasquier, Jérôme ; Galbete, J.L. ; Mermod, Nicolas

In: Bioinformatics, 2007, vol. 23, no. 23, p. 3185-3192

Motivation: Regulatory gene networks contain generic modules such as feedback loops that are essential for the regulation of many biological functions. The study of the stochastic mechanisms of gene regulation is instrumental for the understanding of how cells maintain their expression at levels commensurate with their biological role, as well as to engineer gene expression switches of...