In: Frontiers in Neural Circuits, 2020, vol. 14, p. -
Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CSTPs originating from the premotor cortex (PM) or the primary motor cortex (M1) in two groups of adult macaque monkeys. The first group...
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In: Advanced Materials, 2020, vol. 32, no. 17, p. 1906512
The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐ based innovation toward clinical use calls for further advances in materials, manufacturing and characterization paradigms, and design rules. Herein, a ...
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In: CNS Neuroscience & Therapeutics, 2019, p. cns.13213
In spinal cord injured adult mammals, neutralizing the neurite growth inhibitor Nogo‐A with antibodies promotes axonal regeneration and functional recovery, although axonal regeneration is limited in length. Neurotrophic factors such as BDNF stimulate neurite outgrowth and protect axotomized neurons. Can the effects obtained by neutralizing Nogo‐A, inducing an environment favorable for...
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In: Neurorehabilitation and Neural Repair, 2019, vol. 33, no. 7, p. 553–567
Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The...
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In: Frontiers in Neuroanatomy, 2019, vol. 13, p. -
The corticotectal projections, together with the corticobulbar (corticoreticular) projections, work in parallel with the corticospinal tract (CST) to influence motoneurons in the spinal cord both directly and indirectly via the brainstem descending pathways. The tectospinal tract (TST) originates in the deep layers of the superior colliculus. In the present study, we analyzed the...
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In: Intensive Care Medicine, 2014, vol. 40, no. 3, p. 412-421
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In: Nature Neuroscience, 2018, vol. 21, no. 12, p. 1728–1741
Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount of...
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In: European Journal of Neuroscience, 2018, vol. 48, no. 4, p. 2050–2070
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In: Nature Protocols, 2018, vol. 13, no. 9, p. 2031–2061
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted...
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In: Acta Neuropathologica, 2013, vol. 126, no. 1, p. 159-159
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