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Università della Svizzera italiana

Serum immunoglobulin a cross-strain blockade of human noroviruses

Lindesmith, Lisa C. ; Beltramello, Martina ; Swanstrom, Jesica ; Jones, Taylor A. ; Corti, Davide ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Open forum infectious diseases, 2015, vol. 2, no. 3, p. ofv084

Background: Human noroviruses are the leading cause of acute viral gastroenteritis, justifying vaccine development despite a limited understanding of strain immunity. After genogroup I (GI).1 norovirus infection and immunization, blockade antibody titers to multiple virus-like particles (VLPs) increase, suggesting that GI cross-protection may occur. Methods: Immunoglobulin (Ig)A was purified...