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Université de Fribourg

Different Mi-2 Complexes for Various Developmental Functions in Caenorhabditis elegans

Passannante, Myriam ; Marti, Claude-Olivier ; Pfefferli, Catherine ; Moroni, Paolo S. ; Kaeser-Pebernard, Stéphanie ; Puoti, Alessandro ; Hunziker, Peter ; Wicky, Chantal ; Müller, Fritz

In: PLoS ONE, 2010, vol. 5, no. 10, p. e13681

Biochemical purifications from mammalian cells and Xenopus oocytes revealed that vertebrate Mi-2 proteins reside in multisubunit NuRD (Nucleosome Remodeling and Deacetylase) complexes. Since all NuRD subunits are highly conserved in the genomes of C. elegans and Drosophila, it was suggested that NuRD complexes also exist in invertebrates. Recently, a novel dMec complex, composed of dMi-2 and...

Université de Fribourg

The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans

Guerry, Frédéric ; Marti, Claude-Olivier ; Zhang, Yue ; Moroni, Paolo S. ; Jaquiéry, Emilie ; Müller, Fritz

In: Developmental Biology, 2007, vol. 206, no. 2, p. 469-479

The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and...