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Heterogeneous hydrolytic features for OXA-48-like β-lactamases

Oueslati, Saoussen ; Nordmann, Patrice ; Poirel, Laurent

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 4, p. 1059-1063

Heterogeneous hydrolytic features for OXA-48-like β-lactamases

Oueslati, Saoussen ; Nordmann, Patrice ; Poirel, Laurent

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 4, p. 1059-1063

Objectives: Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ...