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Université de Fribourg

Metabotropic glutamate receptor 5 in bulimia nervosa

Mihov, Yoan ; Treyer, Valerie ; Akkus, Funda ; Toman, Erika ; Milos, Gabriella ; Ametamey, Simon M. ; Johayem, Anass ; Hasler, Gregor

In: Scientific Reports, 2020, vol. 10, no. 1, p. 6374

Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 matched controls. We measured mGlu5 distribution...

Université de Fribourg

Food vs money? Effects of hunger on mood and behavioral reactivity to reward in anorexia nervosa

Piccolo, Mayron ; Milos, Gabriella ; Bluemel, Sena ; Schumacher, Sonja ; Müller-Pfeiffer, Christoph ; Fried, Michael ; Ernst, Monique ; Martin-Soelch, Chantal

In: Appetite, 2019, vol. 134, p. 26-33

BACKGROUND: Previous studies using neuroimaging and behavioral measures reported altered reward processing in anorexia nervosa (AN). In addition, anhedonia states are frequently reported in AN, potentially due to the physiological stress produced by the permanent starvation. We investigated the effect of fasting and satiety on mood and reaction times to monetary rewards in AN patients and healthy...

Université de Fribourg

Altered circulating endocannabinoids in anorexia nervosa during acute and weight‐restored phases: A pilot study

Piccolo, Mayron ; Claussen, Malte Cristian ; Bluemel, Sena ; Schumacher, Sonja ; Cronin, Annette ; Fried, Michael ; Goetze, Oliver ; Martin‐Soelch, Chantal ; Milos, Gabriella

In: European Eating Disorders Review, 2020, vol. 28, no. 1, p. 46-54

Anorexia nervosa (AN) is an eating disorder characterized by a low food intake and often exceeding exercise, leading to a particularly low body × weight proportion. Patients with AN usually report less hunger than healthy controls. Endogenous endocannabinoids (eCBs), specifically the anandamide, have been associated to hunger, as a meal initiator, but research regarding AN and eCB and...