In: eLife, 2020, vol. 9, p. e57915
Conjugative transfer of the integrative and conjugative element ICEclc in Pseudomonas requires development of a transfer competence state in stationary phase, which arises only in 3–5% of individual cells. The mechanisms controlling this bistable switch between non-active and transfer competent cells have long remained enigmatic. Using a variety of genetic tools and epistasis experiments in...
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In: SIAM Journal on Applied Mathematics, 2019, vol. 79, no. 4, p. 1173–1196
We investigate a broad family of stochastically modeled reaction networks by looking at their stationary distributions. Most known results on stationary distributions assume weak reversibility and zero deficiency. We first explicitly give product-form stationary distributions for a class of mostly non-weakly-reversible autocatalytic reaction networks of arbitrary deficiency. We provide...
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In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478
Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...
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In: Scientific Reports, 2018, vol. 8, no. 1, p. 11272
Organisms use environmental cues for directed navigation. Understanding the basic logic behind navigational decisions critically depends on the complexity of the nervous system. Due to the comparably simple organization of the nervous system of the fruit fly larva, it stands as a powerful model to study decision-making processes that underlie directed navigation. We have quantitatively...
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In: Bulletin of Mathematical Biology, 2009, vol. 71, no. 6, p. 1394-1431
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In: Journal of Mathematical Biology, 2007, vol. 55, no. 2, p. 249-269
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In: Journal of Mathematical Biology, 2005, vol. 51, no. 2, p. 198-216
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In: PLOS Computational Biology, 2018, vol. 14, no. 2, p. e1005988
The consensus that complexity begets stability in ecosystems was challenged in the seventies, a result recently extended to ecologically-inspired networks. The approaches assume the existence of a feasible equilibrium, i.e. with positive abundances. However, this key assumption has not been tested. We provide analytical results complemented by simulations which show that equilibrium...
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In: Environmental Microbiology, 2018, vol. 20, no. 1, p. 241–258
Whole-cell bacterial bioreporters are proposed as alternatives to chemical analysis of, for example, pollutants in environmental compartments. Commonly based on reporter gene induction, bioreporters produce a detectable signal within 30 min to a few hours after exposure to the chemical target, which is impractical for applications aiming at a fast response. In an attempt to attain faster...
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In: Nucleic Acids Research, 2011, vol. 39, no. 15, p. e104-e104
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