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    2 results 1
    Université de Fribourg

    Mechanism of cystathionine-β-synthase inhibition by disulfiram : The role of bis(N,N-diethyldithiocarbamate)-copper(II)

    Zuhra, Karim ; Panagaki, Theodora ; B.Randi, Elisa ; Augsburger, Fiona ; Blondel, Marc ; Friocourt, Gaelle ; Herault, Yann ; Szabo, Csaba

    In: Biochemical Pharmacology, 2020, vol. 182, p. 114267

    Background: Hydrogen sulfide (H2S) is an endogenous mammalian gasotransmitter. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3- mercaptopyruvate sulfurtransferase (3-MST) are the principal enzymes responsible for its biogenesis. A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of...

    Université de Fribourg

    The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

    Ahmad, Akbar ; Vieira, Juliana de Camargo ; Mello, Aline Haas de ; Lima, Thais Martins de ; Ariga, Suely Kubo ; Barbeiro, Denise Frediani ; Barbeiro, Hermes Vieira ; Szczesny, Bartosz ; Törö, Gábor ; Druzhyna, Nadiya ; B.Randi, Elisa ; Marcatti, Michela ; Toliver-Kinsky, Tracy ; Kiss, András ; Liaudet, Lucas ; Salomao, Reinaldo ; Soriano, Francisco Garcia ; Szabo, Csaba

    In: Pharmacological Research, 2019, vol. 145, p. 104263

    Poly(ADP-ribose) polymerase (PARP) is involved in the pathogenesis of cell dysfunction, inflammation and organ failure during septic shock. The goal of the current study was to investigate the efficacy and safety of the clinically approved PARP inhibitor olaparib in experimental models of oxidative stress in vitro and in sepsis in vivo. In mice subjected to cecal ligation and puncture (CLP)...

    2 results 1