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The human transmembrane protease serine 2 is necessary for the production of group 2 influenza A virus pseudotypes

Ferrara, Francesca ; Molesti, Eleonora ; Böttcher-Friebertshäuser, Eva ; Cattoli, Giovanni ; Corti, Davide ; Scott, Simon D. ; Temperton, Nigel J.

In: Journal of molecular and genetic medicine, 2013, vol. 7, p. 309-314

The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can cleave the HA of human seasonal influenza viruses. Consequently, we have investigated the use of human Transmembrane Protease Serine 2 to...