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    Université de Fribourg

    Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

    Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

    In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

    Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...

    Université de Fribourg

    Jagged1 is altered in alzheimer’s disease and regulates spatial memory processing

    Marathe, Swananda ; Jaquet, Muriel ; Annoni, Jean-Marie ; Alberi, Lavinia

    In: Frontiers in Cellular Neuroscience, 2017, vol. 11, p. -

    Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability, we investigated whether Jagged1 expression was altered in brain specimen of AD patients. We found...