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EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Pfeiffer, Friederike ; Schäfer, Julia ; Lyck, Ruth ; Makrides, Victoria ; Brunner, Sarah ; Schaeren-Wiemers, Nicole ; Deutsch, Urban ; Engelhardt, Britta

In: Acta Neuropathologica, 2011, vol. 122, no. 5, p. 601-614

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation

Minten, Carsten ; Alt, Carsten ; Gentner, Melanie ; Frei, Elisabeth ; Deutsch, Urban ; Lyck, Ruth ; Schaeren-Wiemers, Nicole ; Rot, Antal ; Engelhardt, Britta

In: Brain, 2014, vol. 137, no. 5, p. 1454-1469

Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection

Zeis, Thomas ; Graumann, Ursula ; Reynolds, Richard ; Schaeren-Wiemers, Nicole

In: Brain, 2008, vol. 131, no. 1, p. 288-303

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder

Lossos, Alexander ; Elazar, Nimrod ; Lerer, Israela ; Schueler-Furman, Ora ; Fellig, Yakov ; Glick, Benjamin ; Zimmerman, Bat-El ; Azulay, Haim ; Dotan, Shlomo ; Goldberg, Sharon ; Gomori, John M. ; Ponger, Penina ; Newman, J. P. ; Marreed, Hodaifah ; Steck, Andreas J. ; Schaeren-Wiemers, Nicole ; Mor, Nofar ; Harel, Michal ; Geiger, Tamar ; Eshed-Eisenbach, Yael ; Meiner, Vardiella ; Peles, Elior

In: Brain, 2015, vol. 138, no. 9, p. 2521-2536

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

Lindner, Maren ; Thümmler, Katja ; Arthur, Ariel ; Brunner, Sarah ; Elliott, Christina ; McElroy, Daniel ; Mohan, Hema ; Williams, Anna ; Edgar, Julia M. ; Schuh, Cornelia ; Stadelmann, Christine ; Barnett, Susan C. ; Lassmann, Hans ; Mücklisch, Steve ; Mudaliar, Manikhandan ; Schaeren-Wiemers, Nicole ; Meinl, Edgar ; Linington, Christopher

In: Brain, 2015, vol. 138, no. 7, p. 1875-1893