Université de Fribourg

Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults

Müller, Sabrina Theresia ; Buchmann, Andreas ; Haynes, Melanie ; Ghisleni, Carmen ; Ritter, Christopher ; Tuura, Ruth ; Hasler, Gregor

In: Heliyon, 2020, vol. 6, no. 5, p. e04025

The brain's major inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and the brain-derived neurotrophic factor (BDNF) play important roles in several stress- related disorders. Magnetic resonance spectroscopy (MRS) allows for non-invasive quantification of GABA concentration in the brain. We investigated the relationship between GABA concentration in the left dorsolateral prefrontal...

Université de Fribourg

Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy

Hasler, Gregor ; Buchmann, Andreas ; Haynes, Melanie ; Müller, Sabrina Theresia ; Ghisleni, Carmen ; Brechbühl, Sarela ; Tuura, Ruth

In: Translational Psychiatry, 2019, vol. 9, no. 1, p. 170

There is growing evidence for GABA and glutamate–glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is...