Université de Fribourg

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*

Durmaz, Esra ; Rajpurohit, Subhash ; Betancourt, Nicolas ; Fabian, Daniel K. ; Kapun, Martin ; Schmidt, Paul ; Flatt, Thomas

In: Evolution, 2019, vol. 73, no. 9, p. 1774–1792

A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single‐nucleotide polymorphism in insulin/insulin‐like growth factor...

Université de Fribourg

Genomic evidence for adaptive inversion clines in Drosophila melanogaster

Kapun, Martin ; Fabian, Daniel K. ; Goudet, Jérôme ; Flatt, Thomas

In: Molecular Biology and Evolution, 2016, vol. 33, no. 5, p. 1317–1336

Clines in chromosomal inversion polymorphisms—presumably driven by climatic gradients—are common but there is surprisingly little evidence for selection acting on them. Here we address this long-standing issue in Drosophila melanogaster by using diagnostic single nucleotide polymorphism (SNP) markers to estimate inversion frequencies from 28 whole-genome Pool-seq samples collected from 10...

Université de Fribourg

Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America

Fabian, Daniel K. ; Kapun, Martin ; Nolte, Viola ; Kofler, Robert ; Schmidt, Paul S. ; Schlötterer, Christian ; Flatt, Thomas

In: Molecular Ecology, 2012, vol. 21, no. 19, p. 4748–4769

Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that has spread to temperate regions and become cosmopolitan, offers a powerful opportunity for identifying the molecular polymorphisms underlying clinal adaptation. Here, we use genome‐wide next‐...

Université de Fribourg

Evolution of longevity improves immunity in Drosophila

Fabian, Daniel K. ; Garschall, Kathrin ; Klepsatel, Peter ; Santos-Matos, Gonçalo ; Sucena, Élio ; Kapun, Martin ; Lemaitre, Bruno ; Schlötterer, Christian ; Arking, Robert ; Flatt, Thomas

In: Evolution Letters, 2018, vol. 2, no. 6, p. 567–579

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in...