Université de Fribourg

Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest

Leonardi, Nora ; Richiardi, Jonas ; Gschwind, Markus ; Simioni, Samanta ; Annoni, Jean-Marie ; Schluep, Myriam ; Vuilleumier, Patrik ; Ville, Dimitri Van De

In: NeuroImage, 2013, p. -

Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in the resting brain. However, an increasing amount of evidence points to non-stationarity of FC; i.e., FC dynamically changes over time reflecting additional and rich information about brain organization, but...

Université de Fribourg

Multiple sclerosis decreases explicit counterfactual processing and risk taking in decision making

Simioni, Samanta ; Schluep, Myriam ; Bault, Nadège ; Coricelli, Giorgio ; Kleeberg, Joerg ; Pasquier, Renaud A. Du ; Gschwind, Markus ; Vuilleumier, Patrik ; Annoni, Jean-Marie

In: PLoS ONE, 2012, vol. 7, no. 12, p. e50718

Deficits in decision making (DM) are commonly associated with prefrontal cortical damage, but may occur with multiple sclerosis (MS). There are no data concerning the impact of MS on tasks evaluating DM under explicit risk, where different emotional and cognitive components can be distinguished.Methods: We assessed 72 relapsing-remitting MS (RRMS) patients with mild to moderate disease and 38...