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IL-12 protects from psoriasiform skin inflammation

Kulig, Paulina ; Musiol, Stephanie ; Freiberger, Sandra Nicole ; Schreiner, Bettina ; Gyülveszi, Gabor ; Russo, Giancarlo ; Pantelyushin, Stanislav ; Kishihara, Kenji ; Alessandrini, Francesca ; Kündig, Thomas ; Sallusto, Federica ; Hofbauer, Günther F.L. ; Haak, Stefan ; Becher, Burkhard

In: Nature communications, 2016, vol. 7, p. 13466

Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. Aside from neutralizing IL-23, which is thought to be responsible for the curative effect, anti-p40 therapy also interferes with IL-12 signalling and type 1 immunity. Here we dissect the individual contribution of these two cytokines to the...

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain

Becher, Burkhard ; Bechmann, Ingo ; Greter, Melanie

In: Journal of Molecular Medicine, 2006, vol. 84, no. 7, p. 532-543

Modeling multiple sclerosis in laboratory animals

Schreiner, Bettina ; Heppner, Frank ; Becher, Burkhard

In: Seminars in Immunopathology, 2009, vol. 31, no. 4, p. 479-495

Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo

Akhmedov, Alexander ; Rozenberg, Izabela ; Paneni, Francesco ; Camici, Giovanni G. ; Shi, Yi ; Doerries, Carola ; Sledzinska, Anna ; Mocharla, Pavani ; Breitenstein, Alexander ; Lohmann, Christine ; Stein, Sokrates ; von Lukowicz, Tobias ; Kurrer, Michael O. ; Borén, Jan ; Becher, Burkhard ; Tanner, Felix C. ; Landmesser, Ulf ; Matter, Christian M. ; Lüscher, Thomas F.

In: European Heart Journal, 2014, vol. 35, no. 40, p. 2839-2848

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Winnik, Stephan ; Lohmann, Christine ; Richter, Eva K. ; Schäfer, Nicola ; Song, Wen-Liang ; Leiber, Florian ; Mocharla, Pavani ; Hofmann, Janin ; Klingenberg, Roland ; Borén, Jan ; Becher, Burkhard ; FitzGerald, Garret A. ; Lüscher, Thomas F. ; Matter, Christian M. ; Beer, Jürg H.

In: European Heart Journal, 2011, vol. 32, no. 20, p. 2573-2584

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

Stein, Sokrates ; Lohmann, Christine ; Schäfer, Nicola ; Hofmann, Janin ; Rohrer, Lucia ; Besler, Christian ; Rothgiesser, Karin M. ; Becher, Burkhard ; Hottiger, Michael O. ; Borén, Jan ; McBurney, Michael W. ; Landmesser, Ulf ; Lüscher, Thomas F. ; Matter, Christian M.

In: European Heart Journal, 2010, vol. 31, no. 18, p. 2301-2309