Université de Fribourg

Amide proton transfer weighted imaging shows differences in multiple sclerosis lesions and white matter hyperintensities of presumed vascular origin

Sartoretti, Elisabeth ; Sartoretti, Thomas ; Wyss, Michael ; Becker, Anton S. ; Schwenk, Árpád ; Smoorenburg, Luuk van ; Najafi, Arash ; Binkert, Christoph ; Thoeny, Harriet C. ; Zhou, Jinyuan ; Jiang, Shanshan ; Graf, Nicole ; Czell, David ; Sartoretti-Schefer, Sabine ; Reischauer, Carolin

In: Frontiers in Neurology, 2019, vol. 10, p. -

Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healthy WM) with APTw signal intensity of MSL and WHM.Materials and Methods: A...

Université de Fribourg

Nine hole peg test and transcranial magnetic stimulation: useful to evaluate dexterity of the hand and disease progression in amyotrophic lateral sclerosis

Czell, David ; Neuwirth, Christoph ; Weber, Markus ; Sartoretti-Schefer, Sabine ; Gutzeit, Andreas ; Reischauer, Carolin

In: Neurology Research International, 2019, vol. 2019, p. 1–5

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since the loss of fine motor skills is one of the earliest signs of ALS, the hypothesis was tested if the nine hole PEG test (NHPT) and transcranial magnet stimulation (TMS) with resting-motor threshold (RMT) could be useful in monitoring disease progression. Methods. We...

Université de Fribourg

Sex and age dependencies of aqueductal cerebrospinal fluid dynamics parameters in healthy subjects

Sartoretti, Thomas ; Wyss, Michael ; Sartoretti, Elisabeth ; Reischauer, Carolin ; Hainc, Nicolin ; Graf, Nicole ; Binkert, Christoph ; Najafi, Arash ; Sartoretti-Schefer, Sabine

In: Frontiers in Aging Neuroscience, 2019, vol. 11, p. 199

Objectives: To assess the influence of age and sex on 10 cerebrospinal fluid (CSF) flow dynamics parameters measured with an MR phase contrast (PC) sequence within the cerebral aqueduct at the level of the intercollicular sulcus.Materials and Methods: 128 healthy subjects (66 female subjects with a mean age of 52.9 years and 62 male subjects with a mean age of 51.8 years) with a normal Evans...