Université de Fribourg

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

Dimova, Ivanka ; Hlushchuk, Ruslan ; Makanya, Andrew N. ; Styp-Rekowska, Beata ; Ceausu, Amalia ; Flueckiger, Stefanie ; Lang, Sonja ; Semela, David ; Le Noble, Ferdinand ; Chatterjee, Suvro ; Djonov, Valentin

In: Angiogenesis, 2013, p. 1-17

Notch is an intercellular signaling pathway related mainly to sprouting neo- angiogenesis. The objective of our study was to evaluate the angiogenic mechanisms involved in the vascular augmentation (sprouting/intussusception) after Notch inhibition within perfused vascular beds using the chick area vasculosa and MxCreNotch1(lox/lox) mice. In vivo monitoring combined with morphological ...

Université de Fribourg

Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy

Templin, Christian ; Meyer, Martin ; Müller, Maja Franziska ; Djonov, Valentin ; Hlushchuk, Ruslan ; Dimova, Ivanka ; Flueckiger, Stefanie ; Kronen, Peter ; Sidler, Michele ; Klein, Karina ; Nicholls, Flora ; Ghadri, Jelena-Rima ; Weber, Klaus ; Paunovic, Dragica ; Corti, Roberto ; Hoerstrup, Simon P. ; Lüscher, Thomas F. ; Landmesser, Ulf

In: European Heart Journal, 2010, vol. 31, no. 14, p. 1792-1801

Aims Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel...