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    Università della Svizzera italiana

    Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex

    Macagno, Annalisa ; Bernasconi, Nadia L. ; Vanzetta, Fabrizia ; Dander, Erica ; Sarasini, Antonella ; Revello, Maria Grazia ; Gerna, Giuseppe ; Sallusto, Federica ; Lanzavecchia, Antonio

    In: Journal of Virology, 2010, vol. 84, no. 2, p. 1005-1013

    Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe disease in immunocompromised patients and infected fetuses. By immortalizing memory B cells from HCMV-immune donors, we isolated a panel of human monoclonal antibodies that neutralized at extremely low concentrations (90% inhibitory concentration [IC90] values ranging from 5 to 200 pM) HCMV infection of...