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HTLV-1 propels thymic human T cell development in “human immune system” Rag2-/- gamma c-/- Mice

Villaudy, Julien ; Wencker, Mélanie ; Gadot, Nicolas ; Gillet, Nicolas A. ; Scoazec, Jean-Yves ; Gazzolo, Louis ; Manz, Markus G. ; Bangham, Charles R. M. ; Duc Dodon, Madeleine

In: Plos pathogens, 2011, vol. 7, no. 9, p. e1002231

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that TaxHTLV-1 interferes with ß- selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human αβ T-cell development. To...