Université de Fribourg

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina Evelyn ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horschg, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: NeuroImage: Clinical, 2020, vol. 26, p. 102193

Introduction: Anhedonia, a core symptom of Major Depressive Disorder (MDD), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. Exposure to stressful life events is another important risk factor for MDD. However, the mechanisms linking reward-deficit and stress to MDD remain poorly understood. Here,...

Université de Fribourg

Food vs money? Effects of hunger on mood and behavioral reactivity to reward in anorexia nervosa

Piccolo, Mayron ; Milos, Gabriella ; Bluemel, Sena ; Schumacher, Sonja ; Müller-Pfeiffer, Christoph ; Fried, Michael ; Ernst, Monique ; Martin-Soelch, Chantal

In: Appetite, 2019, vol. 134, p. 26-33

BACKGROUND: Previous studies using neuroimaging and behavioral measures reported altered reward processing in anorexia nervosa (AN). In addition, anhedonia states are frequently reported in AN, potentially due to the physiological stress produced by the permanent starvation. We investigated the effect of fasting and satiety on mood and reaction times to monetary rewards in AN patients and healthy...

Université de Fribourg

Behavioral Responses to Uncertainty in Weight-Restored Anorexia Nervosa – Preliminary Results

Piccolo, Mayron ; Milos, Gabriella Franca ; Bluemel, Sena ; Schumacher, Sonja ; Mueller-Pfeiffer, Christoph ; Fried, Michael ; Ernst, Monique ; Martin-Soelch, Chantal

In: Frontiers in Psychology, 2019, p. 1-5

Impaired decision-making under conditions of uncertainty seems to contribute to theexpression and maintenance of anorexia nervosa (AN), but it is not clear whether thisimpairment is a disease state that would remit with treatment, or a persisting trait inpatients with AN. To examine this question, a longitudinal study was conducted in12 female inpatients with AN (age M = 22.2, SE = 1.36), before...

Université de Fribourg

Striatal responsiveness to reward under threat‐of‐shock and working memory load : A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Torrisi, Salvatore ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina E. ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horsch, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: Brain and Behavior, 2019, no. 9, p. 1-21

Introduction: Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational...