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A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus

Egli, Adrian ; Levin, Aviad ; Santer, Deanna M. ; Joyce, Michael ; O'Shea, Daire ; Thomas, Brad S. ; Lisboa, Luiz F. ; Barakat, Khaled ; Bhat, Rakesh ; Fischer, Karl P. ; Houghton, Michael ; Tyrrell, D. Lorne ; Kumar, Deepali ; Humar, Atul

In: The Journal of Infectious Diseases