Université de Fribourg

Reduced skeletal muscle protein turnover and thyroid hormone metabolism in adaptive thermogenesis that facilitates body fat recovery during weight regain

Calonne, Julie ; Isacco, Laurie ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Montani, Jean-Pierre ; Guillet, Christelle ; Boirie, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2019, vol. 10, p. -

Objective: The recovery of body composition after weight loss is characterized by an accelerated rate of fat recovery (preferential catch-up fat) resulting partly from an adaptive suppression of thermogenesis. Although the skeletal muscle has been implicated as an effector site for such thrifty (energy conservation) metabolism driving catch-up fat, the underlying mechanisms remain to be...

Université de Fribourg

Standing economy: does the heterogeneity in the energy cost of posture maintenance reside in differential patterns of spontaneous weight-shifting?

Miles-Chan, Jennifer L. ; Fares, Elie-Jacques ; Berkachy, Redina ; Jacquet, Philippe ; Isacco, Laurie ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: European Journal of Applied Physiology, 2017, vol. 117, no. 4, p. 795–807

Due to sedentarity-associated disease risks, there is much interest in methods to increase low-intensity physical activity. In this context, it is widely assumed that altering posture allocation can modify energy expenditure (EE) to impact body-weight regulation and health. However, we have recently shown the existence of two distinct phenotypes pertaining to the energy cost of...

Université de Fribourg

Reliability of low‐power cycling efficiency in energy expenditure phenotyping of inactive men and women

Fares, Elie-Jacques ; Isacco, Laurie ; Monnard, Cathriona R. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Physiological Reports, 2017, vol. 5, no. 9, p. e13233

Standardized approaches to assess human energy expenditure (EE) are well defined at rest and at moderate to high‐intensity exercise, but not at light intensity physical activities energetically comparable with those of daily life (i.e., 1.5–4 times the resting EE, i.e., 1.5–4 METs). Our aim was to validate a graded exercise test for assessing the energy cost of low‐intensity dynamic...