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Evidence against a direct role of klotho in insulin resistance

Lorenzi, Olivier ; Veyrat-Durebex, Christelle ; Wollheim, Claes ; Villemin, Pascal ; Rohner-Jeanrenaud, Françoise ; Zanchi, Anne ; M. Vischer, Ulrich

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 459, no. 3, p. 465-473

Erratum to: Evidence against a direct role of klotho in insulin resistance

Lorenzi, Olivier ; Veyrat-Durebex, Christelle ; Wollheim, Claes ; Villemin, Pascal ; Rohner-Jeanrenaud, Françoise ; Zanchi, Anne ; Vischer, Ulrich

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 460, no. 1, p. 219-219

Preserving of postnatal leptin signaling in obesity-resistant lou/c rats following a perinatal high-fat diet

Poher, Anne-Laure ; Arsenijevic, Denis ; Asrih, Mohamed ; Dulloo, Abdul G. ; Jornayvaz, François R. ; Rohner-Jeanrenaud, Françoise ; Veyrat-Durebex, Christelle

In: PLOS ONE, 2016, vol. 11, no. 9, p. e0162517

Physiological processes at adulthood, such as energy metabolism and insulin sensitivity may originate before or weeks after birth. These underlie the concept of fetal and/or neonatal programming of adult diseases, which is particularly relevant in the case of obesity and type 2 diabetes. The aim of this study was to determine the impact of a perinatal high fat diet on energy metabolism and on...

Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes

Altirriba, Jordi ; Poher, Anne-Laure ; Caillon, Aurélie ; Arsenijevic, Denis ; Veyrat-Durebex, Christelle ; Lyautey, Jacqueline ; Dulloo, Abdul G. ; Rohner-Jeanrenaud, Françoise

In: Endocrinology, 2014, vol. 155, no. 11, p. 4189–4201

Oxytocin has been suggested as a novel therapeutic against obesity, because it induces weight loss and improves glucose tolerance in diet-induced obese rodents. A recent clinical pilot study confirmed the oxytocin-induced weight-reducing effect in obese nondiabetic subjects. Nevertheless, the mechanisms involved and the impact on the main comorbidity associated with obesity, type 2 diabetes,...

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage

Marcelino, Helena ; Veyrat-Durebex, Christelle ; Summermatter, Serge ; Sarafian, Delphine ; Miles-Chan, Jennifer L. ; Arsenijevic, Denis ; Zani, Fabio ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni ; Rohner-Jeanrenaud, Françoise ; Dulloo, Abdul G.

In: Diabetes, 2013, vol. 62, no. 2, p. 362-372

Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose...