Université de Fribourg

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging : Preclinical investigation and dosimetry

Buchegger, F. ; Viertl, D. ; Baechler, Sébastien ; Dunet, V. ; Kosinski, M. ; Poitry-Yamate, C. ; Rüegg, Curzio ; Prior, J. O.

In: Nuklearmedizin, 2011, vol. 50, no. 6, p. 221-246

Aim: To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. Methods: NODAGA-RGDyK (ABX) was labeled with the 68Ga eluate from the 68Ge generator IGG100 using the processor unit PharmTracer. Biodistribution was measured in female Hsd mice sacrificed 10, 30, 60 and 90 min after i.v. injection...

Université de Fribourg

Two non-destructive neutron inspection techniques : prompt gamma-ray activation analysis and cold neutron tomography

Baechler, Sébastien ; Dousse, Jean-Claude (Dir.) ; Jolie, Jan (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1381.

Two non-destructive inspection techniques employing both cold neutron beams have been developed at the Swiss spallation source SINQ of the Paul Scherrer Institute: (1) prompt gamma-ray activation analysis (PGAA) and (2) neutron tomography. PGAA is a nuclear analytical method for identifying and quantifying simultaneously the elements contained in a sample. The technique consists in detecting...

Université de Fribourg

The cold neutron tomography set-up at SINQ

Materna, T. ; Baechler, Sébastien ; Jolie, J. ; Masschaele, B. ; Dierick, M. ; Kardjilov, N.

In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2004, vol. 525, p. 69-73

The cold neutron tomography station operated at SINQ (Paul Scherrer Institute, Switzerland) is reviewed. The high neutron flux together with a set-up based on a scintillator screen and a CCD camera yielded fast and effective results with resolution down to 250 μm: tomography of small samples (up to 2 cm large) could be performed in less than an hour. The use of a velocity selector improved the...