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    Université de Fribourg

    Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem

    Pozzi, Cecilia ; Luca, Filomena De ; Benvenuti, Manuela ; Poirel, Laurent ; Nordmann, Patrice ; Rossolini, Gian Maria ; Mangani, Stefano ; Docquier, Jean-Denis

    In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 12, p. 7189–7199

    BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obtained at pH 5.6, and the structure of native BEL-1 was determined from...