Université de Fribourg

A randomized comparison of platelet reactivity in patients after treatment with various commercial clopidogrel preparations: The CLO-CLO trial = Étude randomisée comparant la réactivité plaquettaire des patients traités par diverses préparations commerciales de clopidogrel. Étude CLO-CLO

Oberhänsli, Markus ; Lehner, Cédric ; Puricel, Serban ; Lehmann, Sonja ; Togni, Mario ; Stauffer, Jean-Christophe ; Baeriswyl, Gérard ; Goy, Jean-Jacques ; Cook, Stéphane

In: Archives of Cardiovascular Diseases, 2012, vol. 105, no. 11, p. 587–592

BackgroundThe salt linked to the clopidogrel molecule in generic preparations is suspected to affect its clinical efficacy. There is a lack of information about inhibition of platelet reactivity by generic preparations.AimsTo compare the effect of original clopidogrel (clopidogrel bisulphate [Plavix®]), generic clopidogrel preparations (clopidogrel hydrochloride...