Università della Svizzera italiana

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...

Université de Fribourg

Stress impacts the regulation neuropeptides in the rat hippocampus and prefrontal cortex

Li, Wenxue ; Papilloud, Aurelie ; Lozano-Montes, Laura ; Zhao, Nan ; Ye, Xueting ; Zhang, Xiaozhe ; Sandi, Carmen ; Rainer, Gregor

In: PROTEOMICS, 2018, vol. 18, no. 7, p. 1700408

Adverse life experiences increase the lifetime risk to several stress‐related psychopathologies, such as anxiety or depressive‐like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked...

Consortium of Swiss Academic Libraries

Breaking the Dynamics of Emotions and Fear in Conflict and Reconstruction

Luterbacher, Urs ; Sandi, Carmen

In: Peace Economics, Peace Science and Public Policy, 2014, vol. 20, no. 3, p. 479-522