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Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

Hotz, Christian ; Treinies, Marina ; Mottas, Inès ; Rötzer, Laurin C. ; Oberson, Anne ; Spagnuolo, Lorenzo ; Perdicchio, Maurizio ; Spinetti, Thibaud ; Herbst, Tina ; Bourquin, Carole

In: OncoImmunology, 2016, vol. 5, no. 11, p. e1232219

Toll-like receptor (TLR) 7 agonists are effective in topical application for the immunotherapy of skin cancers, but their performance for the systemic treatment of solid tumors is limited by the development of TLR tolerance. In this study, we describe a novel strategy to overcome TLR tolerance and enhance TLR7-dependent antitumor immune responses through reprogramming of TLR signaling...