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Université de Fribourg

Draft genome sequence of the virulent Clostridium chauvoei reference strain JF4335

Falquet, Laurent ; Calderon-Copete, Sandra P. ; Frey, Joachim

In: Genome Announcements, 2013, vol. 1, no. 4, p. -

Clostridium chauvoei is the etiological agent of blackleg, a disease of cattle and sheep with high mortality rates, causing severe economic losses in livestock production. Here, we report the draft genome sequence of the virulent C. chauvoei strain JF4335 (2.8 Mbp and 28% G+C content) and the annotation of the genome.

Université de Fribourg

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Liljander, Anne ; Sacchini, Flavio ; Stoffel, Michael H. ; Schieck, Elise ; Stokar‑Regenscheit, Nadine ; Labroussaa, Fabien ; Heller, Martin ; Salt, Jeremy ; Frey, Joachim ; Falquet, Laurent ; Goovaerts, Danny ; Jores, Joerg

In: Veterinary Research, 2019, vol. 50, no. 1, p. 10

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do site-directed mutagenesis. This work describes the establishment of a novel caprine challenge...

Université de Fribourg

Genetic separation of Listeria monocytogenes causing central nervous system infections in animals

Aguilar-Bultet, Lisandra ; Nicholson, Pamela ; Rychener, Lorenz ; Dreyer, Margaux ; Goezel, Bulent ; Origgi, Francesco C. ; Oevermann, Anna ; Frey, Joachim ; Falquet, Laurent

In: Frontiers in Cellular and Infection Microbiology, 2018, vol. 8, p. -

Listeria monocytogenes is a foodborne pathogen that causes abortion, septicemia, gastroenteritis and central nervous system (CNS) infections in ruminants and humans. L. monocytogenes strains mainly belong to two distinct phylogenetic groups, named lineages I and II. In general, clinical cases in humans and animals, in particular CNS infections, are caused by lineage I strains, while most of...

Université de Fribourg

Clostridium chauvoei, an evolutionary dead-end pathogen

Rychener, Lorenz ; In-Albon, Saria ; Djordjevic, Steven P. ; Nicholson, Pamela ; Chowdhury, Piklu Roy ; Ziech, Rosangela E. ; Vargas, Agueda C. de ; Frey, Joachim ; Falquet, Laurent

In: Frontiers in Microbiology, 2017, vol. 8, p. -

Full genome sequences of 20 strains of Clostridium chauvoei, the etiological agent of blackleg of cattle and sheep, isolated from four different continents over a period of 64 years (1951–2015) were determined and analyzed. The study reveals that the genome of the species C. chauvoei is highly homogeneous compared to the closely related species C. perfringens, a widespread pathogen that...