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    Université de Fribourg

    Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

    Widmer, Yves F ; Fritsch, Cornelia ; Jungo, Magali M ; Almeida, Silvia ; Egger, Boris ; Sprecher, Simon G

    In: eLife, 2018, vol. 7, p. e39196

    Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the...

    Université de Fribourg

    Mushroom body-specific profiling of gene expression identifies regulators of long-term memory in Drosophila

    Widmer, Yves F ; Bilican, Adem ; Bruggmann, Rémy ; Sprecher, Simon G

    Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short- term memory traces rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory...

    Université de Fribourg

    A microfluidics-based method for measuring neuronal activity in Drosophila chemosensory neurons

    Giesen, Lena van ; Neagu-Maier, G Larisa ; Kwon, Jae Young ; Sprecher, Simon G

    In: Nature Protocols, 2016, vol. 11, no. 12, p. 2389–2400

    Monitoring neuronal responses to defined sensory stimuli is a powerful and widely used approach for understanding sensory coding in the nervous system. However, providing precise, stereotypic and reproducible cues while concomitantly recording neuronal activity remains technically challenging. Here we describe the fabrication and use of a microfluidics system that allows precise temporally...