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Université de Fribourg

Comparison of cannabinoid concentrations in oral fluid and whole blood between occasional and regular cannabis smokers prior to and after smoking a cannabis joint

Fabritius, Marie ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean Marie ; Dao, Kim ; Favrat, Bernard ; Fornari, Eleonora ; Lauer, Estelle ; Maeder, Philippe ; Giroud, Christian

In: Analytical and Bioanalytical Chemistry, 2013, vol. 405, no. 30, p. 9791–9803

A cross-over controlled administration study of smoked cannabis was carried out on occasional and heavy smokers. The participants smoked a joint (11 % Δ9-tetrahydrocannabinol (THC)) or a matching placebo on two different occasions. Whole blood (WB) and oral fluid (OF) samples were collected before and up to 3.5 h after smoking the joints. Pharmacokinetic analyses were obtained from these data....