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Of marsupials and men: “Backdoor” dihydrotestosterone synthesis in male sexual differentiation

Biason-Lauber, Anna ; Miller, Walter L. ; Pandey, Amit V. ; Flück, Christa E.

In: Molecular and Cellular Endocrinology, 2013, vol. 371, no. 1-2, p. 124–132

Following development of the fetal bipotential gonad into a testis, male genital differentiation requires testicular androgens. Fetal Leydig cells produce testosterone that is converted to dihydrotestosterone in genital skin, resulting in labio-scrotal fusion. An alternative ‘backdoor’ pathway of dihydrotestosterone synthesis that bypasses testosterone has been described in marsupials, but...