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Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation

Hlushchuk, Ruslan ; Riesterer, Oliver ; Baum, Oliver ; Wood, Jeanette ; Gruber, Guenther ; Pruschy, Martin ; Djonov, Valentin

In: American Journal of Pathology, 2009, vol. 173, p. 1173-1185

Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment cessation. To assess the responses to irradiation and vascular endothelial growth factor-receptor tyrosine kinase inhibition (by the vascular endothelial growth factor tyrosine kinase inhibitor PTK787/ZK222854), mammary carcinoma allografts were investigated by vascular...