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Université de Fribourg

Structure and mechanism of ATP-dependent phospholipid transporters

López-Marqués, Rosa L. ; Poulsen, Lisbeth Rosager ; Bailly, Aurélien ; Geisler, Markus ; Pomorski, Thomas Günther ; Palmgren, Michael G.

In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, p. -

Background: ATP-binding cassette (ABC) transporters and P4-ATPases are two large and seemingly unrelated families of primary active pumps involved in moving phospholipids from one leaflet of a biological membrane to the other.Scope of review: This review aims to identify common mechanistic features in the way phospholipid flipping is carried out by two evolutionarily unrelated families of...