Université de Fribourg

TWISTED DWARF1 mediates the action of auxin transport inhibitors on actin cytoskeleton dynamics

Zhu, Jinsheng ; Bailly, Aurelien ; Zwiewka, Marta ; Sovero, Valpuri ; Donato, Martin Di ; Ge, Pei ; Oehri, Jacqueline ; Aryal, Bibek ; Hao, Pengchao ; Linnert, Miriam ; Burgardt, Noelia Inés ; Lücke, Christian ; Weiwad, Matthias ; Michel, Max ; Weiergräber, Oliver H. ; Pollmann, Stephan ; Azzarello, Elisa ; Mancuso, Stefano ; Ferro, Noel ; Fukao, Yoichiro ; Hoffmann, Céline ; Wedlich-Söldner, Roland ; Friml, Jiří ; Thomas, Clément ; Geisler, Markus

In: The Plant Cell, 2016, vol. 28, no. 4, p. 930–948

Plant growth and architecture is regulated by the polar distribution of the hormone auxin. Polarity and flexibility of this process is provided by constant cycling of auxin transporter vesicles along actin filaments, coordinated by a positive auxin-actin feedback loop. Both polar auxin transport and vesicle cycling are inhibited by synthetic auxin transport inhibitors, such as...

Université de Fribourg

Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to increased cell elongation and hypermorphic growth

Bailly, Aurélien ; Wang, Bangjun ; Zwiewka, Marta ; Pollmann, Stephan ; Schenck, Daniel ; Lüthen, Hartwig ; Schulz, Alexander ; Friml, Jiri ; Geisler, Markus

In: The Plant Journal, 2014, vol. 77, no. 1, p. 108–118

Plant growth is achieved predominantly by cellular elongation, which is thought to be controlled on several levels by apoplastic auxin. Auxin export into the apoplast is achieved by plasma membrane efflux catalysts of the PIN-FORMED (PIN) and ATP-binding cassette protein subfamily B/phosphor-glycoprotein (ABCB/PGP) classes; the latter were shown to depend on interaction with the FKBP42, TWISTED...

Université de Fribourg

Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane

Wang, Bangjun ; Bailly, Aurélien ; Zwiewka, Marta ; Henrichs, Sina ; Azzarello, Elisa ; Mancuso, Stefano ; Maeshima, Masayoshi ; Friml, Jiří ; Schulz, Alexander ; Geisler, Markus

In: The Plant Cell, 2013, vol. 25, no. 1, p. 202-214

Plant architecture is influenced by the polar, cell-to-cell transport of auxin that is primarily provided and regulated by plasma membrane efflux catalysts of the PIN-FORMED and B family of ABC transporter (ABCB) classes. The latter were shown to require the functionality of the FK506 binding protein42 TWISTED DWARF1 (TWD1), although underlying mechanisms are unclear. By genetic manipulation of...