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    Université de Fribourg

    Different Roles of BDNF in Nucleus Accumbens Core versus Shell during the Incubation of Cue-Induced Cocaine Craving and Its Long-Term Maintenance

    Li, Xuan ; DeJoseph, M.R. ; Urban, Janice H. ; Bahi, Amine ; Dreyer, Jean-Luc ; Meredith, Gloria E. ; Ford, Kerstin A. ; Ferrario, Carrie R. ; Loweth, Jessica A. ; Wolf, Marina E.

    In: The Journal of Neuroscience, 2013, vol. 33, no. 3, p. 1130-1142

    Brain-derived neurotrophic factor (BDNF) contributes to diverse types of plasticity, including cocaine addiction. We investigated the role of BDNF in the rat nucleus accumbens (NAc) in the incubation of cocaine craving over 3 months of withdrawal from extended access cocaine self-administration. First, we confirmed by immunoblotting that BDNF levels are elevated after this cocaine regimen on...