In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 8, p. 2318-2320
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In: Microbial Drug Resistance, 2019, vol. 25, no. 5, p. 663–667
The aim of the study was to decipher the mechanisms and associated genetic determinants responsible for increased carbapenem resistance among Proteus mirabilis clinical isolates.Methods: The entire genetic structure surrounding the β- lactam resistance genes was characterized by PCR, gene walking, and DNA sequencing.Results: A series of clinical P. mirabilis isolates were consecutively ...
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In: Nucleic Acids Research, 2010, vol. 38, no. 13, p. 4254-4262
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In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 75-80
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In: International Immunology, 1999, vol. 11, no. 3, p. 461-469
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In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 12, p. 7245–7251
The blaNDM-1 gene encodes a carbapenemase that confers resistance to almost all β-lactams, including last-resort carbapenems. This is increasingly reported worldwide in nosocomial and community-acquired Gram-negative bacteria. Acinetobacter baumannii is an important opportunistic pathogen that is considered an intermediate reservoir for the blaNDM-1 gene. In this species, the blaNDM-1 gene...
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In: Journal of Antimicrobial Chemotherapy, 2016, p. dkw139
The aim of the study was to develop a simple assay for rapid detection of the mcr-1 gene, recently identified as a source of plasmid-mediated acquired resistance to polymyxins in Enterobacteriaceae.Methods: A SYBR Green-based real-time PCR assay was designed for detection of the mcr-1 gene. This assay was applied to cultured bacteria and to spiked human and cattle stools.Results: The mcr-1...
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In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 5, p. 3032–3040
The species Acinetobacter baumannii is one of the most important multidrug-resistant human pathogens. To determine its virulence and antibiotic resistance determinants, the genome of the nosocomial blaNDM-1-positive A. baumannii strain R2090 originating from Egypt was completely sequenced. Genome analysis revealed that strain R2090 is highly related to the...
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In: Antimicrobial Agents and Chemotherapy, 2015, p. AAC.04450–14
Resistance to ß-lactams is constantly increasing, due to the emergence of totally new enzymes, but also to the evolution of pre-existing ß-lactamases. GES-1 is a clinically-relevant extended-spectrum β-lactamase (ESBL) hydrolyzing penicillins and broad-spectrum cephalosporins, but sparing monobactams and carbapenems. However, several GES-1 variants (i.e. GES-2 and GES-5) previously identified...
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In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 75-80
Objectives Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae.Methods...
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