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Université de Fribourg

The role of clock genes and rhythmicity in the liver

Schmutz, Isabelle ; Albrecht, Urs ; Ripperger, Jürgen A.

In: Molecular and Cellular Endocrinology, 2011, p. -

The liver is the important organ to maintain energy homeostasis of an organism. To achieve this, many biochemical reactions run in this organ in a rhythmic fashion. An elegant way to coordinate the temporal expression of genes for metabolic enzymes relies in the link to the circadian timing system. In this fashion not only a maximum of synchronization is achieved, but also anticipation of daily...

Université de Fribourg

“Feeding time” for the brain: A matter of clocks

Feillet, Céline A. ; Albrecht, Urs ; Challet, Etienne

In: Journal of Physiology-Paris, 2006, vol. 100, no. 5-6, p. 252-260

Circadian clocks are autonomous time-keeping mechanisms that allow living organisms to predict and adapt to environmental rhythms of light, temperature and food availability. At the molecular level, circadian clocks use clock and clock-controlled genes to generate rhythmicity and distribute temporal signals. In mammals, synchronization of the master circadian clock located in the suprachiasmatic...