In: Journal of Biological Rhythms, 2006, vol. 21(3), p. 169-176
In mammals, circadian rhythms in behavior and physiology are controlled by a central pacemaker, the SCN, and subordinated clocks throughout the body. On the molecular level, these clocks are based on transcriptional/translational feedback loops involving a set of clock genes that regulate their own transcription. Among the components driving the mammalian circadian clock are the Period 1...
|
In: Biological Procedures Online, 2005, vol. 7, p. 101-116
Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that...
|
Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.
To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...
|
In: Journal of Biological Rhythms, 2004, vol. 19, no. 1, p. 22-34
The blind subterranean mole rat superspecies Spalax ehrenbergi is an extreme example of mammalian adaptation to life underground. Though this rodent is totally visually blind, harboring a drastically degenerated subcutaneous rudimentary eye, its daily activity rhythm is entrainable to LD cycles. This indicates that it confers light information to the clock, as has been previously shown by the...
|