Université de Fribourg

REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

Chavan, Rohit ; Preitner, Nadia ; Okabe, Takashi ; Mansencal Strittmatter, Laureen ; Xu, Cheng ; Ripperger, Jürgen A. ; Pitteloud, Nelly ; Albrecht, Urs

In: Biology Open, 2017, vol. 6, no. 1, p. 1–7

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of...

Université de Fribourg

REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor

Okabe, Takashi ; Chavan, Rohit ; Costa, Sara S. Fonseca ; Brenna, Andrea ; Ripperger, Jürgen A. ; Albrecht, Urs

In: Journal of Cell Science, 2016, vol. 129, no. 21, p. 4143–4154

REV-ERBα (encoded by Nr1d1) is a nuclear receptor that is part of the circadian clock mechanism and regulates metabolism and inflammatory processes. The glucocorticoid receptor (GR, encoded by Nr3c1) influences similar processes, but is not part of the circadian clock, although glucocorticoid signaling affects resetting of the circadian clock in peripheral tissues. Because of their similar...

Université de Fribourg

Liver-derived ketone bodies are necessary for food anticipation

Chavan, Rohit ; Feillet, Céline ; Costa, Sara S. Fonseca ; Delorme, James E. ; Okabe, Takashi ; Ripperger, Jürgen A. ; Albrecht, Urs

In: Nature Communications, 2016, vol. 7, p. 10580

The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific...