Université de Fribourg

Rev‐erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice

Feillet, Céline A. ; Bainier, Claire ; Mateo, Maria ; Blancas-Velázquez, Aurea ; Salaberry, Nora L. ; Ripperger, Jürgen A. ; Albrecht, Urs ; Mendoza, Jorge

In: Addiction Biology, 2017, vol. 22, no. 2, p. 411–422

The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are driven by the brain suprachiasmatic clock. How the circadian clock impacts on...

Université de Fribourg

Food for thoughts: feeding time and hormonal secretion

Feillet, Céline A.

In: Journal of Neuroendocrinology, 2010, p. -

Many daily cycles are imposed on us by our environment, such as alternating days and nights, temperature fluctuations or rhythms in food availability. When food is accessible every day at the same time, animals will adapt their physiology and behaviour to match the daily meal. They will anticipate the access to food by waking up and being active in the hours prior to feeding, foraging for food....

Université de Fribourg

“Feeding time” for the brain: A matter of clocks

Feillet, Céline A. ; Albrecht, Urs ; Challet, Etienne

In: Journal of Physiology-Paris, 2006, vol. 100, no. 5-6, p. 252-260

Circadian clocks are autonomous time-keeping mechanisms that allow living organisms to predict and adapt to environmental rhythms of light, temperature and food availability. At the molecular level, circadian clocks use clock and clock-controlled genes to generate rhythmicity and distribute temporal signals. In mammals, synchronization of the master circadian clock located in the suprachiasmatic...

Université de Fribourg

Forebrain oscillators ticking with different clock hands

Feillet, Céline A. ; Mendoza, Jorge ; Albrecht, Urs ; Pévet, Paul ; Challet, Etienne

In: Molecular and Cellular Neuroscience, 2008, vol. 37, no. 2, p. 209-221

Clock proteins like PER1 and PER2 are expressed in the brain, but little is known about their functionality outside the main suprachiasmatic clock. Here we show that PER1 and PER2 were neither uniformly present nor identically phased in forebrain structures of mice fed ad libitum. Altered expression of the clock gene Cry1 was observed in respective Per1 or Per2 mutants. In response to hypocaloric...

Université de Fribourg

Lack of Food Anticipation in Per2 Mutant Mice

Feillet, Céline A. ; Ripperger, Jürgen A. ; Magnone, Maria Chiara ; Dulloo, Abdul G. ; Albrecht, Urs ; Challet, Etienne

In: Current Biology, 2006, vol. 16, no. 20, p. 2016-2022

Predicting time of food availability is key for survival in most animals. Under restricted feeding conditions, this prediction is manifested in anticipatory bouts of locomotor activity and body temperature. This process seems to be driven by a food-entrainable oscillator independent of the main, light-entrainable clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus 1 and 2....