Université de Fribourg

Aminergic signaling controls ovarian dormancy in drosophila

Andreatta, Gabriele ; Kyriacou, Charalambos P. ; Flatt, Thomas ; Costa, Rodolfo

In: Scientific Reports, 2018, vol. 8, no. 1, p. 2030

In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay ...

Université de Fribourg

Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock

Bee, Leonardo ; Marini, Selena ; Pontarin, Giovanna ; Ferraro, Paola ; Costa, Rodolfo ; Albrecht, Urs ; Celotti, Lucia

In: Nucleic Acids Research, 2015, vol. 43, no. 4, p. 2126-2137

The efficiency of Nucleotide Excision Repair (NER)process is crucial for maintaining genomic integrity because in many organisms, including humans, it represents the only system able to repair a wide range of DNA damage. The aim of the work was to investigate whether the efficiency of the repair of photoproducts induced by UV-light is affected by the circadian phase at which irradiation occurred....