Université de Fribourg

Altered sleep homeostasis in rev-erbα knockout mice

Mang, Géraldine M. ; La Spada, Francesco ; Emmenegger, Yann ; Chappuis, Sylvie ; Ripperger, Jürgen A. ; Albrecht, Urs ; Franken, Paul

In: SLEEP, 2016, vol. 39, no. 3, p. 589–601

Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of...

Université de Fribourg

The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis

Schnell, Anna ; Chappuis, Sylvie ; Schmutz, Isabelle ; Brai, Emanuele ; Ripperger, Jürgen A. ; Schaad, Olivier ; Welzl, Hans ; Descombes, Patrick ; Alberi, Lavinia ; Albrecht, Urs

In: PLoS ONE, 2014, vol. 9, no. 6, p. e99883

The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and...

Université de Fribourg

Age-dependent alterations in human PER2 levels after early morning blue light exposure

Jud, Corinne ; Chappuis, Sylvie ; Revell, Victoria L. ; Sletten, Tracey L. ; Saaltink, Dirk-Jan ; Cajochen, Christian ; Skene, Debra J. ; Albrecht, Urs

In: Chronobiology International, 2009, vol. 26, no. 7, p. 1462-1469

In our modern society, we are exposed to different artificial light sources that could potentially lead to disturbances of circadian rhythms and, hence, represent a risk for health and welfare. Investigating the acute impact of light on clock-gene expression may thus help us to better understand the mechanisms underlying disorders rooted in the circadian system. Here, we show an overall...