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Université de Fribourg

Age-dependent alterations in human PER2 levels after early morning blue light exposure

Jud, Corinne ; Chappuis, Sylvie ; Revell, Victoria L. ; Sletten, Tracey L. ; Saaltink, Dirk-Jan ; Cajochen, Christian ; Skene, Debra J. ; Albrecht, Urs

In: Chronobiology International, 2009, vol. 26, no. 7, p. 1462-1469

In our modern society, we are exposed to different artificial light sources that could potentially lead to disturbances of circadian rhythms and, hence, represent a risk for health and welfare. Investigating the acute impact of light on clock-gene expression may thus help us to better understand the mechanisms underlying disorders rooted in the circadian system. Here, we show an overall...

Université de Fribourg

Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans

Cajochen, Christian ; Jud, Corinne ; Münch, Mirjam ; Kobialka, Szymon ; Wirz-Justice, Anna ; Albrecht, Urs

In: European Journal of Neuroscience, 2006, vol. 23, no. 4, p. 1082-1086

We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant...